Unique Weapon Locations

[Dovahkiin1995]

these are the locations of some of the unique weapon locations some easily found and others more difficult

Maria: Unique 9mm pistol located on Benny's corpse or pickpocketed

Lucky: Unique .357 magnum found in a hard locked floor safe in the Bison Steve Hotel in Primm the safe is in the gift shop. Note: a convict may occasionally take Lucky and use it against you.

That Gun: Unique gun found in the Dino Bite Gift Shop in Novac purchased from Cliff Briscoe or stolen from the store room. It is unique in the sense that it uses 5.56 rounds and can only be repaired at merchats or with weapon repair kits.

All American: Unique marksman carbine found in the Vault 34 Armory ocasionally collected by companions

Dinner Bell: Unique hunting shotgun received as a reward for completing Bleed Me Dry

CZ57 Avenger: Unique mini gun located in The Devil's Throat next to a dead prospector guarded by Evolved Centaurs. Note: there is a glitch where the gun wont appear mainly on Xbox.

Golden Gloves: Unique boxing gloves located in the Lucky 38 in the V.I.P. cocktail lounge on the casino level.

Chopper: Unique cleaver located in the wolfhorn ranch on the stove it is a larger version of the cleaver and is rusted.

Hope these locations helped.  

[XxCrimson_ShinobixX]

These are very helpful, thanks!
 

[Renji Abarai The Great]

the super sledge oh baby can be found in the mountain cave located behind jacobstown  

[Dovahkiin1995]

This one's a little confusing

Alien Blaster or YCS/186. The YCS/186 is the unique Gauss Rifle it can be aquired at the Mercenary Camp. BUT IF you took the wild wasteland trait you get the Alien Blaster instead of the YCS/186. The merc camp is an unmarked location north of Horowitz Farmstead. If you have Wild Wasteland its an Alien Landing Site.  

[Dovahkiin1995]

Renji Abarai The Great

the super sledge oh baby can be found in the mountain cave located behind jacobstown

only when youre on the quest to investigate the nightstalkers  

[Chaos Fenrir slayer]

THIS MACHINE! : got it from the dealing with contreaces, contreces, contt?
okay that unmarked quest, hack his computer, then go to boyd, then give her the proof (at camp mccaran)

Albilene kid le bb gun : It can be found in Fields' Shack, southwest of Nellis Air Force Base. The shack is right next to the main road leading in to the base. The gun is sitting on one of the shelves on the left wall.
If you have the Wild Wasteland trait, the gun will instead be located inside a well that appears in front of the shack. The well appears upon talking to Rex upon him saying ¨aroo¨ and asking him if someone fell down a well. Doing this will cause you to receive a map marker denoting the location of Jimmy's Well.

La Longue Carabine : Can be found in Camp McCarran near New vegas, it is carried by an old Ranger by the name of Corporal Sterling. He is part of the quest I Don't Hurt Anymore and killing him for the rifle will forfeit the quest.

After killing Driver Nephi and returning to Major Dhatri as part of the quest Three-Card Bounty, the 1st recon unit will move to Camp Forlorn Hope. You can find them all together next to the Jailhouse in the northwestern part of the camp.

Ratslayer : Inside the Broc Flower Cave, on/below a desk in the cement fortification.

Gobi Campaign scout rifle : It can be found in a locked footlocker, although in order to obtain it you will need 100 lock picking skill (very hard) and it is located in Sniper's Nest, due west and up the hill from Cottonwood Cove.

Vance's 9mm submachine gun : The weapon is missing from its display case in the Vikki and Vance Casino, but Primm Slim does not notice this fact. With high enough Science skill (50), however, you will gain a dialog option to reveal that the weapon was taken to Wins Hideout, where it can be found inside the safe with a very hard lock. The lock can be picked, or with a high enough Speech skill (55) you can convince the Wins to give you the combination or if you don't have enough speech for the speech check talk to Sammy again and another dialog will appear

Big Boomer : The Big Boomer is carried by Old Lady Gibson, who resides in the Gibson Scrapyard. The weapon can be looted from her body, or shot out of her hands in combat (she'll become non-hostile if you quickly holster your weapon afterward).
It can also be obtained by first pickpocketing the 12 gauge shotgun shells off of Old Lady Gibson, initiating combat with her, holstering your weapon, then after several attempts, it is possible to take it off of her.
It can also be obtained through a bug. Sometimes Lady Gibson along with her dogs and possibly a Mole Rat or two will enter HELIOS One while the player is there and immediately attack.
Like the La Longue Carabine, you can reverse pickpocket the 12 gauge shotgun shells that she has in her inventory, save, wait a day, enter and exit her "garage" and then reverse pickpocket the Big Boomer. (Tried while she was asleep, worked better)

Euclid's C-Finder : In Freeside, outside of Mick & Ralph's, you can find Max during the day. You can pay Max 1000 caps (or 20 caps with 45 Barter) for his "toy gun" C-Finder. You can also wait until he goes to bed, usually after 9pm, then pickpocket him to get the gun.

Pew Pew :This weapon can be found inside the Sunset Sarsaparilla Headquarters after presenting to Festus at least 50 Sunset Sarsaparilla star bottle caps and beginning the quest A Valuable Lesson. The weapon is found next to the body of Allen Marks but is not in his inventory.

AER14 prototype : The AER14 Prototype laser rifle is located in Vault 22 common area. To obtain it, go to the fifth floor, Pest Control, and enter the stairway door to the common area which has a lock with a difficulty that varies according to the players level. The AER14 is laying on the ground next to a scorched skeleton.

Mercy biggrin ead Wind Cavern - By a dead Brotherhood of Steel soldier along with some 40mm grenades, 40mm incendiary grenades and T-45d Power armor and helmet.It is guarded by many Young Deathclaws, Deathclaws, Mother Deathclaw and the Legendary Deathclaw.

Annabelle :Found on the Nightkin sniper on the radio tower catwalk at Black Mountain, along with some missiles.

Thump-Thump:Thump-Thump is found in the Nellis Array generators just south/south-east of the two array generator switches during or after the quest Ant Misbehavin'. It is next to two broken generators, by the skeleton.

Tesla-Beaton prototype :The Tesla-Beaton prototype can be found at the Crashed Vertibird next to a skeleton, near the Old Nuclear Test Site far southeast. (Use caution, however, as there may be up to 6 Hardened Mister Gutsies and 3 Hardened Sentry Bots standing guard.)

Q-35 matter modulator :REPCONN Headquarters, behind the very hard locked door at first floor. The very hard terminal next to the door can also be used. Note: Not always a very hard locked door. Also, in lieu of finding keycards or terminals to upload your facial profile to, it is possible to covertly kill all Mr. Handy "Mobile Facial Scanners" without setting off the alarms--however, you must kill them before they talk to you! The other Mr. Handy models can be avoided or destroyed without alerting security provided you are not witnessed or told to vacate the premises in 30 seconds.

Accessing the weapon without 100 in Science or 100 Lockpick:.

* Floor 1
o Take the tour. The tour guide will open the room to the planetarium (average locked door if you do not like the Long tour or the robot is dead) and go to the room back in the left. Walk upstairs and there is a key card for the main floor.
o Go back to the entrance and enter the room at the right (4 dead fiends in front of it) and walk up the stairs. Go to Floor 2.
* Floor 2
o In the room on the left is an easy terminal to add facial data recognition (optional if you have the key card). At the southwest corner of the second floor is a staircase which will guide you to Floor 3.
* Floor 3
o There is a Mr. Handy who asks for the password, with a Luck 7 you can say Ice Cream.(also with a intelligence of 2 you can say ice cream) Otherwise you have 30 seconds to find the next key card (see below) before an alarm sounds, all the Mr. Handy robots turn hostile, and hostile heavy combat bots appear from hidden compartments in the walls. Where the roof collapsed there are lying 2 Brotherhood Paladins (holotape for accessing Hidden Valley) and next to the collapsed roof at the other side (go all the way around) is a skeleton with a briefcase with 200 pre-War money and key card for Floor 3.
* Back to Floor 2
o Get to floor 2 again and find the door for floor 1 access (not the main door. Lockpick 75).
* Back to Floor 1
o Use the keycard on the door and in the next room (where the floor has collapsed) walk in to it and in the right corner you see the Q-35 matter modulator!

If you can't find the correct door on the 2nd floor, you can also unlock the very hard door on the main floor now with the key card to enter the same room.

If you do not meet some of the stat/skill requirements mentioned above, you can simply kill all the hostile robots.

If the gun is not there make sure to check your companions inventory as they may have taken it before you get to it.

Knock-Knock :it is found in Camp Searchlight's Fire Station. Once you get the key from Logan, head upstairs and search the bathroom stalls, look in the right side corner of the stall with the skeleton to find the Knock Knock. You must first complete the quest for Logan to get the key or you can kill Logan.

Liberator :It is given to you by Dead Sea at Camp Nelson after completing the quest We Are Legion. If you are working for the NCR you are sent to kill him for the quest Restoring Hope, and you can take it off his body. Also you can pickpocket it from him.

Figaro : * It is held by Sergio, inside the King's School of Impersonation. It may be looted from his corpse, or obtained via pickpocketing.
* You can loot his corpse without killing him yourself(although the Kings don't seem to mind if you do): Harm Sergio, and when he turns hostile the Kings gang member standing next to him will kill Sergio, yet not turn hostile toward you.

Blade of the East :Can be looted from Legate Lanius in the final battle if siding with the NCR, Yes Man, or House. Note that you will only have a limited time to use this, as the game ends soon after the fight. This makes the weapon's appearence fairly useless, as it cannot be used anywhere else in the game.

Chance's knife :It's located in Chance's grave, north of Goodsprings on a hill near Tribal Village along with Great Khan simple armor. A Shovel is needed to access the loot, the closest one is at the Goodsprings General Store or the player can find a fully repaired one around the Goodsprings Source (leaning against one of the water troughs).  

[Chaos Fenrir slayer]

Nephi's Golf Driver : Kill driver nephi

The Humble Cudgel :The North Sewers are accessed via a door in The Thorn. To get there, enter the Thorn, then follow the north wall, and finally follow the east wall to the corner. Once inside the Northern Sewers, head down to the bottom center of the map where you'll find a large pipe which is the entrance to the Central Sewers. Head straight and take the left at the T intersection (Ghoul Roamers and Giant Rats populate the area) then look NE and see a red light in the next tunnel. That light marks a door, inside will be the corpse of "Blind" Luke, take the key off his corpse as you'll be needing it to access the sealed door. Next, head southeast through the map to find a sandbag wall and a couple of NCR troops in a tunnel.

Additionally, the Central Sewers can be accessed via a manhole outside the main gate to Camp McCarran. Head west where you will encounter several Fiends. Head north at the junction where the fiends were and then east from the room with the four columns. Take a slight left to find the room marked by red lights where "Blind" Luke is located.

Go W past this tunnel and up a couple of ramps to find a group of about five Fiends guarding a door. Go S through the door and the next room to see a set of metal stairs. At the top of the stairs is the door you needed to get the key for. It leads to the Sealed Sewers. Inside the Sealed Sewers there are a handful of assorted Ghouls, including roamers, reavers, and glowing ones. Kill them and in the first room on the left will be a dead Prospector, loot him for The Humble Cudgel. In his duffel bag there's a copy of Lad's Life or ¡La Fantoma!.

Cram Opener : * It is held by Little Buster in Camp McCarran. He can typically be found meleeing a practice dummy just before the tents.
* If you completed the Three-Card Bounty for Major Dhatri, then Little Buster won't be found at the camp. Instead, he ran away to Freeside via the North Gate. His body can be found by following the railroad tracks upon entering Freeside via this gate.
* If you pickpocket the Cram Opener from Little Buster, then complete the bounty hunter missions, you can loot a second Cram Opener from his body in Freeside.

PushyPushy is located in the Ruby Hill Mine, which is northeast of Jacobstown. The location itself is marked by 2-3 bighorners grazing near the entrance. Be advised--the mine is filled with lakelurks. Pushy can be found on the body of a dead Jackal gang member.

Pushy : is also rarely located inside the Van Graff safe. Saving just before attempting to open the safe, and repeating until Pushy is inside is also an option. It is ALSO located in the Ultra-Luxe Penthouse, in a safe upstairs. This option is unwise as there are "Heck Gunderson Hired Hands" patrolling the area and will attack on sight.

Recompense of the Fallen :it can be found inside the Office of Aurelius of Phoenix at Cottonwood Cove, inside his desk.

Love and Hate : Love and Hate can be found on a Viper Gang Leader in Bonnie Springs, a place located almost due North from the Goodsprings Cemetery.

Paladin Toaster : The Paladin Toaster is located in Black Rock Cavern. It is lying on the body of a dead prospector, guarded by Nightkin.  

[Gray_In_Ur_Pokitz]

http://www.youtube.com/watch?v=PB66xHONoog
Heres a unique melee weapons guide (plus the guy is hilarious XD)