Plot:
Ashiya is late on her very first day to Osaka (桜咲) Gakuen, running into Sano (unknown to her at first) and dropping her bag after freaking out, as Sano asked why her hands were so soft. Sano is able to return the bag to her during class however, since they end up being in the same class. His first impression of Mizuki was that she (he) was gay, because she said, "I like you. Let's be friends." Ashiya is also assigned to be Sano's roommate by pure fate. Although she previously believed that she might have time off in forging her masculinity, Mizuki must now keep her false personal about her all day, every day. She is however, overjoyed that she is now Sano's roommate and is determined to be his friend. It also happens fairly early in her time at Osaka High that she is knocked unconscious and she is forced to include the school's doctor, Hokuto Umeda, in on the secret. Unbeknownst to either of them, the same incident that makes Mizuki tell Umeda also reveals her secret to Sano. Sano, however, keeps quiet so that Mizuki would not have to leave, and he could continue to have her by his side.
The story is usually filled with humor and situations that put all characters involved into uncomfortable places, or at least places they wouldn't have thought they would have entered on their own. Additional characters include Shuichi Nakatsu, a fellow student who is confused over his attraction to Mizuki which often drives the plot forward and Minami Nanba, the R.A. of the dorm to which Sano, Mizuki, and Nakatsu belong.
The gender-bending nature of this series gives for many amusing hi-jinx and a lot of laughter, but at the core, the series also has just the amount of drama and romance that makes it so appealing to the normal shojo audience.
Also, the theme of friendship is frequently expressed in the story, from the trio of Sano, Ashiya and Nakatsu to their group of friends: Kayashima, Noe, Sekime and Nakao. These friends helped each other through times of trouble (e.g. Nakao dealing with his feelings for Nanba).
